Role of Homeostatic Changes in Salivary Gland Acinar Cells in Primary Sjogren's Syndrome: A Review
변진석,
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변진석 ( Byun Jin-Seok ) - Kyungpook National University School of Dentistry Department of Oral Medicine
Abstract
Primary Sjogren's syndrome (pSS) is an autoimmune progressive disease characterized by dysfunction and inflammation of the salivary glands. The underlying mechanisms of salivary gland involvement in pSS remain unclear, and researchers have primarily focused on immunological phenomena, making it difficult to distinguish between the cause and effect of the disease. Consequently, our research aims to directly investigate changes in homeostasis occurring in acinar cells, specifically in the context of muscarinic signaling, mucins, aquaporins, and forkhead box protein O1, to elucidate the initial step of pSS. We compare the disease-related phenomena observed in salivary gland acinar cells in pSS with the overall process of salivary secretion.
키워드
Aquaporins; Forkhead box protein O1; Mucins; Muscarinic signaling; Primary Sjogren’s syndrome; Salivary gland acinar cells
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